Trial homepages
ACUMISS
Acupuncture treatment with threatened miscarriage: an exploratory study. Trial being conducted by the Centre for Complementary Medicine Research, University of Western Sydney.
AdDITThe Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial (AdDIT) is a randomised, double blind, placebo controlled trial to investigate the effect of Angiotensin Converting Enzyme Inhibitors (ACEI), Statins, and a combination of both, in patients aged 11-15 with Type I diabetes.
Age of amplificationTrial of age of amplification for infants with unilateral hearing impairment identified by the Newborn Hearing Screening Programme.
BCIS-1Ballon-pump Coronary Intervention Study.
CALMSThe Computer-assisted ALerting and Monitoring System study is a randomised controlled trial of continuous physiological monitoring.
COSAKA randomised phase II study evaluating cediranib vs. cediranib and saracatanib in patients with relapsed metastatic clear cell renal cancer.
CRISPAn international multi-centre open randomised controlled trial of isolated off-pump CABG (OPCABG) versus on-pump CABG (ONCABG) in high risk patients.
Detemir GlargineA comparison of the effects of insulin Detemir with insulin Glargine on weight gain in female adolescents and young adults with Type 1 Diabetes (T1D) on a basal bolus regime.
e-ALSElectronic learning Advanced Life Support (e-ALS) Evaluation. An open label randomised controlled trial to determine whether a 1 day face to face ALS course supplemented by e-learning material is equivalent to the 2 day face to face conventional ALS course in healthcare providers seeking advanced life support training.
Growth HormoneThe Ely low dose growth hormone study - effects of six months administration of low dose growth hormone on insulin sensitivity, post-load glucose tolerance and cardiovascular disease risk markers in subjects with impaired glucose tolerance.
IL-1RA in SAH Biomarker StudyA double blind randomised controlled trial to determine whether IV administered Kineret® inhibits the central nervous system (CNS) inflammatory response in patients with SAH
IMPACTImproving Mood with Psychoanalytic And Cognitive Therapies. Trial of Specialist Clinical Care (SCC) vs. Cognitive Behavioural Therapy (CBT) vs. Short Term Psychoanalytical Psychotherapy (STTP).
IVANA double blind 2x2 factorial randomised controlled trial of VEGF inhibitors for improving visual outcome in patients with CNV from AMD.
LaMBA phase II/III, randomised, two-arm comparison of maintenance lapatinib versus placebo after first-line chemotherapy in patients with HER1 and/or HER2 overexpressing locally advanced or metastatic bladder cancer.
LamotrigineA double blind parallel group randomised controlled trial of neuroprotection with lamotrigine in secondary progressive multiple sclerosis.
MRC-ILA-HEART StudyA proof of concept clinical trial investigating the effects of IL-1ra upon markers of inflammation in patients with Non-ST elevation myocardial infarction.
MS-STATA phase II randomised, placebo-controlled clinical trial of simvastatin in patients with secondary progressive multiple sclerosis.
NEON StudyAmino acid regimen and intravenous lipid composition in preterm parenteral nutrition: a randomised controlled trial of Nutritional Evaluation and Optimisation in Neonates.
NesgasThe North European SGA Study - Treatment with recombinant growth hormone in children born small for gestational age (SGA) without catch-up growth.
NIRTURENeonatal Insulin Replacement Therapy in Europe - a multi-centre, randomised controlled study of early insulin replacement in very low birth weight infants (VLBW <1500g).
NSCLC PSIIPhase III trial of single-agent Pemetrexed (Alimta®) versus the combination of Carboplatin and Pemetrexed in patients with advanced non-small-cell lung cancer and performance status 2.
Pancreas 2000Pancreas 2000 ENSAP - a randomised prospective open label, pragmatic multi-centre trial on the effect of early enteral nutrition on gut barrier permeability in severe acute pancreatitis.
PermitPilot Effectiveness of Randomised Mandatory Insulin Therapy study to investigate safety and mechanisms of this therapy in reducing mortality in critically ill patients.
PhantomCan Pregabalin prevent persistent postamputation pain? A double-blind, placebo controlled trial to investigate whether a single preoperative dose of pregabalin followed by a month of postoperative treatment can significantly reduce the incidence of phantom pain.
Pobble1Peri-operative beta blockade trial 1 - POBBLE1 is a trial to evaluate the effectiveness of beta blockade given before vascular surgery to patients without previous myocardial infarction.
ProdiscL'objectif de cette étude est d'évaluer le rapport coût - efficacité comparé de la prothèse discale lombaire PRODISC et de l'arthrodèse dans le cadre des pathologies lombaires dégénératives d'origine discale.
ProMPTA single-centre randomised controlled trial of propofol cardioplegia on blood and myocardial biomarkers of stress and injury in patients having isolated coronary artery bypass grafting (CABG) or aortic valve replacement (AVR) using cardiopulmonary bypass (CPB)
PulMiCCA Randomised trial of Pulmonary Metastasectomy in Colorectal Cancer. This is a two-stage randomised feasibility study. Patients will be firstly registered for evaluation and if subsequently eligible, randomised to active monitoring versus active monitoring with pulmonary metastasectomy.
REACHCan rehabilitation delivered immediately on hospitalisation for an acute exacerbation of chronic respiratory disease improve long term health outcomes?
REMoxTB (code break)REMoxTB is a study for the "Rapid Evaluation of Moxifloxacin in the treatment of sputum smear positive tuberculosis". REMoxTB aims to find and evaluate new drugs and regimens that shorten the duration of tuberculosis therapy.
REPAIRRandomised double blind placebo-controlled trial to determine if remote ischaemic preconditioning (RIPC) improves renal function after transplantation.
SCATRandomised controlled clinical trial of conventional surgery vs. hybrid surgery for patients undergoing surgery for concomitant valve and coronary disease.
SimSeptSimvastatin and severe sepsis trial.
SPACEA self-management programme for chronic obstructive pulmonary disease: is it effective in primary care?
SteTA randomised controlled trial of median sternotomy vs. anterolateral left thoracotomy on morbidity and healthcare resource use in patients having off-pump coronary artery bypass surgery.
TAPSA multi-centre, randomised controlled trial of pre-operative blood transfusion for patients with sickle cell disease undergoing surgery.
TITRe 2A multi-centre, randomised controlled trial comparing 7.5g/dL versus 9.0g/dL Hb thresholds for blood transfusion after cardiac surgery.
TOPPSTwo-stage, randomised, non-inferiority trial comparing prophylactic platelet use with no-prophylaxis in adult thrombocytopenic patients with haematological malignancies.
TransACTA single centre, double-blind, randomised placebo controlled clinical trial in patients undergoing coronary surgery following a recent anterior STEMI. The objective is to determine the effect of subepicardial injection of enriched autologous CD 133 cells derived from bone marrow into infarcted myocardium on the extent of change in regional wall thickening.
TransACT 2A single centre, randomised-controlled clinical trial in patients undergoing left ventricular restoration surgery for dilated ischemic end-stage heart failure. Participants and all members of the healthcare and research team are blinded to the study allocation.
TRANX-HA randomised controlled trial of the use of topical application of Tranexamic acid in primary total hip replacement.
TRANX-KA double blind controlled randomised trial of patients undergoing unilateral primary cemented total knee replacement. The objective is to find out whether Tranexamic acid will reduce blood loss significantly after total knee replacement when applied topically.
VeRDiCTPreoperative Volume Replacement vs. usual care in Diabetic patients having CABG surgery: a randomised controlled Trial.
Woman (code break)Tranexamic Acid for the Treatment of Postpartum Haemorrhage: an international Randomised, Double Blind, Placebo Controlled Trial.
Zoledronic AcidA double blind randomised controlled trial examining the effect of intravenous zoledronic acid on pleural tumour progression, pleural fluid production, breathlessness and quality of life in patients with malignant pleural disease.