Trial homepages

Age of amplification

Trial of age of amplification for infants with unilateral hearing impairment identified by the Newborn Hearing Screening Programme.

BCIS-1

Ballon-pump Coronary Intervention Study.

CALMS

The Computer-assisted ALerting and Monitoring System study is a randomised controlled trial of continuous physiological monitoring.

Demonstration

Fictional trial giving demonstration of internet randomisation system for evaluation purposes.

Detemir Glargine

A comparison of the effects of insulin Detemir with insulin Glargine on weight gain in female adolescents and young adults with Type 1 Diabetes (T1D) on a basal bolus regime.

e-ALS

Electronic learning Advanced Life Support (e-ALS) Evaluation. An open label randomised controlled trial to determine whether a 1 day face to face ALS course supplemented by e-learning material is equivalent to the 2 day face to face conventional ALS course in healthcare providers seeking advanced life support training.

Growth Hormone

The Ely low dose growth hormone study - effects of six months administration of low dose growth hormone on insulin sensitivity, post-load glucose tolerance and cardiovascular disease risk markers in subjects with impaired glucose tolerance.

IVAN

A double blind 2x2 factorial randomised controlled trial of VEGF inhibitors for improving visual outcome in patients with CNV from AMD.

Lamotrigine

A double blind parallel group randomised controlled trial of neuroprotection with lamotrigine in secondary progressive multiple sclerosis.

MRC-ILA-HEART Study

A proof of concept clinical trial investigating the effects of IL-1ra upon markers of inflammation in patients with Non-ST elevation myocardial infarction.

MS-STAT

A phase II randomised, placebo-controlled clinical trial of simvastatin in patients with secondary progressive multiple sclerosis.

Nesgas

The North European SGA Study - Treatment with recombinant growth hormone in children born small for gestational age (SGA) without catch-up growth.

NIRTURE

Neonatal Insulin Replacement Therapy in Europe - a multi-centre, randomised controlled study of early insulin replacement in very low birth weight infants (VLBW <1500g).

NSCLC PSII

Phase III trial of single-agent Pemetrexed (Alimta®) versus the combination of Carboplatin and Pemetrexed in patients with advanced non-small-cell lung cancer and performance status 2.

Pancreas 2000

Pancreas 2000 ENSAP - a randomised prospective open label, pragmatic multi-centre trial on the effect of early enteral nutrition on gut barrier permeability in severe acute pancreatitis.

Permit

Pilot Effectiveness of Randomised Mandatory Insulin Therapy study to investigate safety and mechanisms of this therapy in reducing mortality in critically ill patients.

Phantom

Can Pregabalin prevent persistent postamputation pain? A double-blind, placebo controlled trial to investigate whether a single preoperative dose of pregabalin followed by a month of postoperative treatment can significantly reduce the incidence of phantom pain.

Pobble1

Peri-operative beta blockade trial 1 - POBBLE1 is a trial to evaluate the effectiveness of beta blockade given before vascular surgery to patients without previous myocardial infarction.

Prodisc

L'objectif de cette étude est d'évaluer le rapport coût - efficacité comparé de la prothèse discale lombaire PRODISC et de l'arthrodèse dans le cadre des pathologies lombaires dégénératives d'origine discale.

SCAT

Randomised controlled clinical trial of conventional surgery vs. hybrid surgery for patients undergoing surgery for concomitant valve and coronary disease.

SimSept

Simvastatin and severe sepsis trial.

SteT

A randomised controlled trial of median sternotomy vs. anterolateral left thoracotomy on morbidity and healthcare resource use in patients having off-pump coronary artery bypass surgery.

TAPS

A multi-centre, randomised controlled trial of pre-operative blood transfusion for patients with sickle cell disease undergoing surgery.

TransACT

A single centre, double-blind, randomised placebo controlled clinical trial in patients undergoing coronary surgery following a recent anterior STEMI. The objective is to determine the effect of subepicardial injection of enriched autologous CD 133 cells derived from bone marrow into infarcted myocardium on the extent of change in regional wall thickening.

TRANX-H

A multi-centre, randomised controlled trial of the use of topical application of Tranexamic acid in primary cemented total hip replacement.

TRANX-K

A double blind controlled randomised trial of patients undergoing unilateral primary cemented total knee replacement. The objective is to find out whether Tranexamic acid will reduce blood loss significantly after total knee replacement when applied topically.