Randomised double blind placebo-controlled trial
Purpose of clinical trial
To determine if remote ischaemic preconditioning (RIPC) improves renal function after transplantation.
Primary objective
To determine the effect of RIPC on glomerular filtration rate (GFR) 12 months after transplantation
Inclusion criteria
- Patients undergoing living donor transplantation
- Patients aged 18 years and above
Exclusion criteria
- 0,0,0-mismatched renal grafts (no mismatch in HLA-A/B/DR antigens between donor and recipient)
- Patients on ATP-sensitive potassium channel opening or blocking drugs
- Patients on ciclosporin
- Patients who have had a previous transplant
- Patients with a known iodine sensitivity (who cannot undergo iohexol clearance studies)
- Any patient requiring HLA antibody removal therapy
- Patients with ABO incompatability
