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The TANDEM Trial: A randomised controlled Trial of high and low dose Avastin® for Neovascular macular Degeneration in the East Midlands.

Wet or neovascular age-related macular degeneration (nAMD) causes severe sight loss in older people. The aim of this trial is to investigate alternative treatment regimens for the treatment of nAMD with Avastin. TANDEM is a factorial, randomised controlled clinical trial which will (a) compare the clinical efficacy of high versus low doses of Avastin and (b) compare monthly versus two-monthly review intervals. The trial will also describe both eye-related and systemic adverse effects observed with different Avastin doses and treatment regimens.

If you require any help, please contact Wendy Underwood:

Email: wendy.underwood@bristol.ac.uk

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