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This trial has now closed. |
A multi-centre, randomised controlled trial of the use of topical application of Tranexamic acid in primary cemented total hip replacement. The objective is to find out whether Tranexamic acid will reduce blood loss significantly after total hip replacement when applied topically.
Inclusion Criteria
- All patients undergoing unilateral primary cemented total hip replacement
Patient Exclusions
- Allergic to Tranexamic acid
- Bleeding tendency (e.g. Haemophilic and ITP)
- Warfarin, treatment dose of LMWH or conventional heparin
- History of DVT and pulmonary embolism
- Paget's disease
- Female subjects of child bearing potential must have a negative pregnancy test
Concomitant treatment
Permitted therapies include:
- Aspirin
- Subcutaneous prophylactic conventional or LMW heparin
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