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PRO2TECTION 1: Pulmonary protection with low frequency ventilation during cardiopulmonary bypass: a prospective randomised study.
Open-heart surgery is carried out on more than 35,000 UK patients each year with an all cause 30-day mortality of 3-4%. However, the numbers of patients experiencing respiratory complications is much higher and is rising due to the increasing number of high-risk patients having open-heart surgery. Complications after surgery place an enormous burden on hospital resources and are associated with increased NHS costs.
The aim of this study is to investigate in a clinical setting the safety and efficacy of a strategy for lung protection during cardiac surgery that involves keeping the lungs ventilated at a low frequency to prevent the detrimental effect of prolonged collapse during CPB; this procedure has been tested and validated in an experimental study. Therefore, we propose to carry out a randomised controlled clinical trial which will compare this strategy of ventilating the lungs during CPB with the current standard practice of collapsing the lungs during the surgery.
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