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Bristol Clinical Trials and Evaluation Unit

PRO2TECTION 1: Pulmonary protection with low frequency ventilation during cardiopulmonary bypass: a prospective randomised study.

Open-heart surgery is carried out on more than 35,000 UK patients each year with an all cause 30-day mortality of 3-4%. However, the numbers of patients experiencing respiratory complications is much higher and is rising due to the increasing number of high-risk patients having open-heart surgery. Complications after surgery place an enormous burden on hospital resources and are associated with increased NHS costs.

The aim of this study is to investigate in a clinical setting the safety and efficacy of a strategy for lung protection during cardiac surgery that involves keeping the lungs ventilated at a low frequency to prevent the detrimental effect of prolonged collapse during CPB; this procedure has been tested and validated in an experimental study. Therefore, we propose to carry out a randomised controlled clinical trial which will compare this strategy of ventilating the lungs during CPB with the current standard practice of collapsing the lungs during the surgery.

If you require any help, please contact:

Email: Dr Graziella Mazza g.mazza@bristol.ac.uk

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