Transfusion Alternatives Pre-operatively in Sickle cell disease

This trial has now closed


A multi-centre, randomised controlled trial of pre-operative blood transfusion for patients with sickle cell disease undergoing surgery. Patients will be recruited from both Europe and North America and randomised to either pre-operative blood transfusion or no pre-operative blood transfusion. The target sample size is 400 over 5 years.


Inclusion Criteria

Patient Exclusions

History of sickle cell complications

History of sickle cell complications is defined as:

If a patient scores 'YES' to ANY of the above, they will be regarded as having sickle cell complication(s).

ISRCTN 00862331

If you require any help, please contact:

Moira Malfroy
Email: moira.malfroy@nbs.nhs.uk

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