Compliance with a high energy content, low volume Oral Nutritional Supplement (ONS)
A randomised controlled trial to investigate the effect of structured education on people at high risk of cardiovascular disease" where name like '3R (Ready to Reduce Risk) study
Evaluating the clinical and cost-effectiveness of permissive hypotension in critically ill patients aged 65 years or over with vasodilatory hypotension
Acetic Acid guided biopsies in Barrett’s surveillance for neoplasia detection versus non-targeted biopsies (Seattle protocol): A feasibility study for a randomised tandem endoscopy trial. The ABBA study
Acetabular Fractures in older patients Intervention Trial. A feasibility study comparing three methods of treatment of acetabular fractures in older patients; surgical fixation versus surgical fixation and hip replacement versus non-surgical treatment
Acupuncture treatment with threatened miscarriage: an exploratory study. Trial being conducted by the Centre for Complementary Medicine Research, University of Western Sydney.
A novel targeted treatment for reducing anxiety in joint hypermobility: a proof of concept study (ADAPT)
Efficacy and tolerability of NL-01, a food ingredient, in older adults at risk of Acute Respiratory Tract Infections (ARTI) during the winter season
Aggression Following Traumatic Brain Injury (TBI): Effectiveness of Risperidone – a Feasibility RCT
AmnioFix for Achilles Tendonitis, Phase III IND
A prospective, randomised, placebo-controlled double blind, multi-centre study of the effects of Irbesartan on aortic dilatation in Marfan syndrome.
AmnioFix Injectable in the Treatment of Knee Osteoarthritis, Phase 2B
AmnioFix for Plantar Fasciitis, Phase III IND
Auto-inflation in children with otitis media with effusion (AIRS). A multi-centre trial being run by the Primary Care Clinical Trials Unit at the University of Oxford.
Attention Training for Learning Enhancement and Resilience Trial
ANTidepressants to prevent reLapse in dEpRession
Evaluating the benefit of Additional Platelet inhibition in Acute Coronary Syndrome patients with high platelet reactivity undergoing PCI. A Randomised comparison of prasugrel versus clopidogrel re-loading in patients with ACS undergoing urgent PCI with persistent high platelet reactivity.
Obstructive sleep apnoea and retinal vasculature reactivity
A randomised phase II study to seek evidence that the addition of a potent src-inhibitor, AZD0530, to conventional aromatase inhibition, delays the onset of endocrine resistance in post- menopausal women with advanced breast cancer.
A randomised trial of expedited transfer to a cardiac arrest centre for non-ST elevation out-of-hospital cardiac arrest (ARREST)
Primary Antibiotic prophylaxis using co-trimoxazole to prevent SpontanEous bacterial PeritoniTIs in Cirrhosis (ASEPTIC)
Combined multi-marker screening and randomised patient treatment with aspirin for evidence-based pre-eclampsia prevention.
The ASSERT (Acute Sacral inSufficiEncy fractuRe augmenTation) Randomised Controlled, Feasibility in Older People) Trial
A randomised, placebo-controlled, double-blind trial of the antidepressant efficacy of a novel CNS-penetrant P2X7 receptor antagonist, JNJ-54175446, in people with major depressive disorder, an incomplete response to monoaminergic antidepressant drugs, and a biomarker profile predictive of active P2X7 signalling
Albumin To prevenT Infection in chronic liveR failurE
Use of Endothelin-1 antagonists in patients with established pulmonary hypertension and fibrotic lung disease - a randomised, placebo controlled, double-blinded study.
Phase 2a two-site randomised controlled trial to determine safety of and adherence with a new ‘Binocularly Balanced Viewing’ treatment for unilateral amblyopia compared with standard treatment in children age 3-8 years
A double-blinded, randomised, placebo-controlled trial of liraglutide 3.0 mg in patients with poor weight-loss and a suboptimal glucagon-like peptide-1 response following bariatric surgery.
Balanced Salt Solution Versus 0.9% Saline Infusion for Prevention of Contrast-induced Acute Kidney Injury
A randomized, controlled trial of the use of a dedicated ballooned intercostal drain
Ballon-pump Coronary Intervention Study.
Safety and efficacy of Belimumab After B cell depleTion therapy in systemic LUPUS erythematosus
A feasibility study of the use of Betashot, a medium chain triglyceride-based (MCT) food for special medical purposes (FSMP) in children and adults with epilepsy.
Pilot cluster randomised trial of an evidence based intervention to reduce avoidable hospital admissions in residents in care homes (the Better Health in Residents in Care Homes study)
A pilot randomised controlled trial of one to one befriending by volunteers, compared to Usual Care, in reducing symptoms of depression in people with intellectual disability (ID)
The Benefit Of Night splinting in Dupuytrens
A feasibility investigating different interventions for the treatment of benign paroxysmal positional vertigo in acute traumatic brain injury patients
BRAVE Trial. Broad-spectrum Cognitive Remediation Available to Veterans: Effects of a Brain Plasticity-based Program in Mild Traumatic Brain Injury (mTBI). Posit Science.
Morphine for the relief of breathlessness in heart failure.
BRIDE (Barrett's Randomised Intervention for Dysplasia by Endoscopy) - a feasibility study
Randomised double-blind controlled trial of connectivity guided theta burst transcranial magnetic stimulation versus repetitive transcranial magnetic stimulation for treatment resistant moderate to severe depression: evaluation of efficacy, cost effectiveness and mechanism of action
BT-LIFE, Brain Tumours, Lifestyle Interventions and Fatigue
Gastric BYpass or adjustable gastric BANDing surgery or Sleeve Gastrectomy surgery to treat morbid obesity: a multi-centre randomised controlled trial.
A phase III, open, randomised, multi-site trial to assess the clinical and cost-effectiveness of early parenteral, compared with early enteral, nutritional support in critically ill patients.
Cambridge Brain Mets Trial 1
A Randomised Controlled Trial for People with Established Type 2 Diabetes during Ramadan: Canagliflozin (Invokana™) vs. standard dual therapy regimen.
The feasibility of recruiting and undertaking a randomised controlled trial to help with coping using two talking interventions, ACT or a Talking Control for people receiving treatment to control their cancer symptoms.
A phase IIa/b, randomised, double-blind, placebo-controlled, single-site, parallel group clinical trial to examine cannabidiol (CBD) as a pharmacological treatment for cannabis dependence in a young cannabis dependent population.
CanTalk: the clinical and cost effectiveness of CBT plus treatment as usual for the treatment of depression in advanced cancer; a randomised controlled trial.
Efficacy, safety and impact on antimicrobial resistance of duration and dose of amoxicillin treatment for young children with Community-Acquired Pneumonia (CAP): A randomised controlled trial
The Coronary Artery Revascularisation in Diabetes (CARDia) trial
A psychological intervention for suicide applied to patients with psychosis: The CARMS trial (Cognitive Approaches to Combatting Suicidality).
A Prospective, Randomised Controlled Trial Comparing Glycaemic Benefits of Active Versus Passive Lifestyle Intervention in Kidney Allograft Recipients.
Efficacy and safety of novel treatment options for adults with COVID-19 pneumonia. A double-blinded, randomized, multi-stage, 6-armed placebo-controlled trial in the framework of an adaptive trial platform
Low-dose atropine eye drops to reduce progression of myopia in children: a multi- centre placebo controlled randomised trial in the United Kingdom, (CHAMP UK)
Congestive Heart failure Cardiopoietic Regenerative Therapy (CHART-1) trial. Efficacy and Safety of Bone Marrow-Derived Mesenchymal Cardiopoietic Cells (C3BS-CQR-1) for the treatment of chronic advanced ischemic Heart Failure. Cardio3 BioSciences SA.
Cholinesterase inhibitors to prevent falls in Parkinson’s Disease: A multicentre, phase III, double blind, randomised control trial of the cholinesterase inhibitor, rivastigmine versus placebo to prevent falls in Parkinson’s disease
A Randomized Trial to confirm the Safety and Effectiveness of Chocolate Touch™ Paclitaxel Coated PTA Balloon Catheter, in Above the Knee Lesions
Randomised controlled trial of the clinical and cost-effectiveness of a contingency management intervention for reduction of cannabis use and of relapse in early psychosis.
A 2x2 factorial randomised examiner blind open label trial to determine the clinical and cost-effectiveness of hypertonic saline (HTS 6%) and carbocisteine for airway clearance versus usual care over 52 weeks in bronchiectasis
A randomised, double blind, controlled mechanistic study of rituximab and belimumab combination therapy in PR3 ANCA-associated vasculitis
Cooling in Mild Encephalopathy Trial (COMET) – Feasibility study
Conventional versus Minimally Invasive extra-corporeal circulation in patients undergoing Cardiac Surgery: a randomised controlled trial
Cognitive behavioural therapy or medication for psychosis - a randomised evaluation.
Comparison trial of open-tip pulsed needle biopsy and conventional core biopsy in axillary lymph nodes (COMPULSE)
A randomised phase II pilot study of 3 weekly Cabazitaxel versus weekly Paclitaxel chemotherapy in the first line treatment of HER2 negative breast cancer.
Increasing uptake and adherence to long-acting reversible contraceptive (LARC) methods in young women
COlchicine for preventioN of Vascular Inflammation in Non-CardioEmbolic stroke – a randomised clinical trial of low-dose colchicine for secondary prevention after stroke
Hypothermia as an adjunctive therapy to percutaneous coronary intervention in patients with acute myocardial infarction.
A Multicenter, Prospective, Randomized Controlled Trial to Assess Cooling as an Adjunctive Therapy to Percutaneous Intervention in Patients with Acute Myocardial Infarction
Multicenter, prospective, randomized-controlled trial to assess the safety and effectiveness of cooling as an adjunctive therapy to percutaneous intervention in patients with acute myocardial infarction
Innovative use of antibiotics in the prevention of exacerbations of chronic obstructive pulmonary disease (COPD).
Reducing perioperative risk in chronic obstructive pulmonary disease with pre-operative pulmonary rehabilitation
A randomised placebo-controlled trial of anti-ST2 in COPD (COPDST₂OP)
Colchicine in Patients with Acute Coronary Syndromes
Effectiveness of a Proactive Cardiovascular Primary Prevention Strategy, With or Without the Use of Coronary Calcium Screening, in Preventing Future Major Adverse Cardiac Events
CORE Phase 3. A randomised controlled trial of a peer-provided self-management intervention for people leaving CRT care.
A randomised phase II study evaluating cediranib vs. cediranib and saracatanib in patients with relapsed metastatic clear cell renal cancer.
Tranexamic acid for the treatment of significant traumatic brain injury: an international randomised, double blind placebo controlled trial
Microbleeds and genetic risk factors to predict the risk of intracranial haemorrhage in patients treated with anticoagulation following cardioembolic stroke due to atrial fibrillation.
Randomised controlled trial comparing the diagnostic yield of Radial Endo-Bronchial Ultra-Sound (R-EBUS) guided Cryo-biopsy Vs. CT guided transthoracic biopsy in patients with parenchymal lung lesion.
Comprehensive moUthcare to Prevent Postoperative pneumoniA
Complete Versus Lesion-only PRimary PCI PiloT Study. Prospective observational registry and open multi-centre randomised controlled trial (RCT) in a subset of patients with multi-vessel coronary artery disease.
Direct Angioplasty for Non ST-Elevation Acute Coronary Events (DANCE Pilot Study). The aim of the DANCE pilot study is to compare an immediate versus delayed revascularisation strategy in high risk patients with non ST elevation Myocardial Infarction (NSTEMI).
A Phase I, Storer Design, open-label, cross-sectional, single site trial of ANX776 in healthy volunteers, progressive glaucoma/glaucoma-suspect/ocular hypertensive subjects and non-arteritic anterior ischaemic optic neuropathy subjects.
A phase II, open label, non-randomised, single centre, clinical trial of ANX776 in healthy volunteers and patients with Glaucoma, Age-Related Macular Degeneration and Optic Neuritis
Dapagliflozin during exercise for the prevention of Hypoglycaemia in Type 1 diabetes – Pilot study
Depletion of Serum Amyloid P Component In Alzheimer’s Disease
Improving Outcomes in Fistula Intervention: A prospective, patient blinded, phase 3, randomised controlled trial of Drug Eluting Balloons in the Angioplasty of Native Haemodialysis Access Arteriovenous Fistula Outflow Stenosis
Diabetes Intervention Accentuating Diet and Enhancing Metabolism (DIADEM-I): a randomised controlled trial assessing the impact of low calorie diet and activity on body weight and glycaemia in diabetes in early diabetes
DIAbetic Macular Oedema aNd Diode Subthreshold micropulse laser
An Investigation to Evaluate an Over-The-Wire FFR Infusion Microcatheter (HYPEREM™IC) for Measuring Fractional Flow Reserve (FFR)
Diabetes Interventional Assessment of Slimming or Training to Lessen Inconspicuous Cardiovascular dysfunction
A pragmatic multi-centre randomised controlled non-inferiority, cost effectiveness trial comparing injections of collagenase into the cord to surgical correction in the treatment of moderate Dupuytren’s Contracture in adult patients.
DIrect or Subacute COronary angiography in out-of-hospital cardiac arrest – a prospective, randomized study
The DHA (docosahexaenoic acid) Oxford Learning and Behaviour (DOLAB II) Study. Does taking an Omega 3 food supplement help children’s learning and behaviour?
Randomised controlled trial of nasal decongestants versus placebo to prolong treatment free periods from continuous positive airway pressure therapy in mild to moderate obstructive sleep apnoea
A Phase II, multicentre, randomised, placebo-controlled, double-masked trial of RP101 ophthalmic formulation versus vehicle in post-menopausal women with moderate to severe dry eye syndrome
DyeVert TP-6495 trial. Mobius Medical Pty Ltd, Australia
Early switch to oral antibiotic therapy in patients with low risk neutropenic sepsis.
A Randomised Controlled Trial of Early valve replacement in severe ASYmptomatic Aortic Stenosis (EASY-AS)
A feasibility study of a psychological intervention to address alcohol misuse for people with mild to moderate learning disabilities living in the community
The second European Carotid Surgery Trial. ECST-2 (ISRCTN 97744893) is an international randomised trial comparing the treatment of mild to moderate carotid stenosis by optimized medical management alone with carotid surgery or stenting and optimized modern medical management.
Understanding the importance of plasticity in the brain mechanisms of dyspnoea perception
A Randomised Placebo Controlled Trial of the effectiveness of Early MEtformin in Addition to Usual Care in the Reduction of Gestational Diabetes Mellitus Effects
An Investigation into the efficacy of Mirococept (APT070) for preventing ischaemia-reperfusion injury in the kidney allograft (EMPIRIKAL). King's College London and Guy's & St Thomas' NHS Foundation Trust.
Randomised, multi-centre study to assess efficacy, tolerability and safety of Enterosgel® in treatment of acute diarrhoea in adults
Evaluation of Parent Intervention for Challenging Behaviour in Children with Intellectual Disabilities
The effect of remote ischaemic preconditioning and glyceryl trinitrate on peri-operative myocardial injury in cardiac bypass surgery patients (ERIC-GTN study) - a four arm randomised, controlled trial.
Effect of Remote Ischaemic Conditioning on clinical outcomes in ST-segment elevation myocardial infarction patients undergoing Primary Percutaneous Coronary Intervention (ERIC-PPCI): A multicentre randomised controlled clinical trial
Effect of Remote Ischaemic preConditioning on clinical outcomes in patients undergoing Coronary Artery Bypass Graft surgery. A multicentre randomised controlled clinical trial to determine whether remote ischaemic preconditioning (RIC) improves clinical outcomes after cardiac surgery.
A Randomised controlled, open label trial of Ex-vivo Normothermic Perfusion versus Static Cold Storage in Donation after Circulatory Death Renal Transplantation
A randomised, double blind, placebo controlled, single centre, 60 week, trial of Exenatide for the treatment of moderate severity Parkinson's disease.
A comprehensive comparison of the sensitivity of common exercise outcome measures for Chronic Obstructive Pulmonary Disease (COPD).
Supporting adults with Type 1 Diabetes (T1DM) to undertake exercise; Developing and piloting an Education programme for exercise in Type 1 diabetes: EXercise for Type 1 Diabetes (EXTOD) education
A Randomised Comparison of Femtosecond Laser Assisted vs Manual Phacoemulsification Cataract Surgery for Adults with Visually Significant Cataract.
Quality-Assured Follow-up of quiescent neovascular age -related maculaR dEgeneration by non-medical practitioners: a randomised controlled trial
A multi-centre, pilot, randomised clinical trial of a more permissive temperature threshold for antipyretic intervention in critically ill children with known or suspected infection
FIRST-line support for Assistance in Breathing in Children (FIRST-ABC): A master protocol of two randomised trials to evaluate the non-inferiority of high flow nasal cannula (HFNC) versus continuous positive airway pressure (CPAP) for non-invasive respiratory support in paediatric critical care
Feeding in Late and Moderately Preterm Infants and Growth Outcomes
An open-label, multi-centre, randomised, parallel design study to assess the efficacy of flash glucose monitoring in adults with type 1 diabetes
Randomised Feasibility Study of a Physiotherapy Programme for Patients with Functional Motor Symptoms (FMS).
Fluoxetine Or Control Under Supervision Poland. A randomised trial to establish the effect(s) of routine administration of Fluoxetine in patients with a recent stroke in Poland.
Finding the optimal cooling tempeRature after Out-of-hoSpiTal cardiac arrest. Zoll Circulation Inc.
Using Real-Time Functional Brain Imaging to Enhance Recovery from TBI. The Geneva Foundation.
Enrolment of patients to a Prospective Multicentre Clinical Surveillance Study To Evaluate The Stability, Efficacy And Safety Of The Furlong Evolution® Hip Stem In Primary Total Hip Arthroplasty.
Implementation of COPD Case Finding and Self-Management Action Plans in Low and Middle Income Countries
The Glooko Diabetes Mobile Monitoring and Management Advantage Study (GL1v3)
Insulin degludec titration using mobile insulin dosing system
Globifer Forte® Oral Haem and Non-haem Iron Supplementation in Heart Failure
A comparison of Glycosade® and Uncooked Cornstarch (UCCS) for the dietary management of hepatic glycogen storage diseases (GSD
Two-armed, double blind, randomised, controlled trial with ursodeoxycholic acid (UDCA) versus placebo for the treatment of Gestational Diabetes Mellitus (GDM)
Tranexamic acid for the treatment of gastrointestinal haemorrhage: an international randomised, double blind placebo controlled trial
Hughes Abdominal Repair Trial
HEAL trial - Hepatic Encephalopathy And LOLA. Efficacy of intravenous 'L-ornithine L-aspartate' in reversal of overt acute hepatic encephalopathy in patients with liver cirrhosis: a prospective, randomized, double-blind, placebo controlled trial.
Hypothermia for Encephalopathy in Low and Middle-Income Countries (HELIX) trial
Randomised controlled trial of a web-based self management programme (HeLP-Diabetes) for people with type 2 diabetes in primary care.
A multicentre randomised controlled trial to evaluate the effect of Heimlich valves on length of stay in patients admitted to hospital with secondary spontaneous pneumothorax.
Human papillomavirus infection: a randomised controlled trial of Imiquimod cream (5%) versus Podophyllotoxin cream (0.15%), in combination with quadrivalent human papillomavirus or control vaccination in the treatment and prevention of recurrence of anogenital warts.
A randomised double-blind, placebo-controlled phase I/IIa trial to investigate the effect of depletion of serum amyloid P component (SAP) on the immune response to DNA vaccination in healthy male volunteers.
HalOPeridol Effectiveness trial. A randomised, double-blind, placebo-controlled trial to compare the early administration of intravenous haloperidol versus placebo in the prevention and treatment of delirium in critically ill ventilated patients.
Randomised controlled trial of hospital at home directed by the DECAF score versus standard inpatient care for patients admitted with an acute exacerbation of COPD and embedded health economic and qualitative studies.
A phase II randomised placebo controlled double blinded trial of Interleukin 1 blockade in Acute Severe Colitis
Iron and Chronic Obstructive Pulmonary Disease COPD Exercise Trial. To test the hypothesis that intravenous iron improves exercise performance in COPD as measured by constant rate cycle ergometry.
ICONS II - Identifying Continence OptioNs after Stroke randomized controlled trial
Kidney Disease in Type 2 Diabetes Mellitus: Biomarker Discovery and Novel Therapeutics.
Improving Mood with Psychoanalytic And Cognitive Therapies. Trial of Specialist Clinical Care (SCC) vs. Cognitive Behavioural Therapy (CBT) vs. Short Term Psychoanalytical Psychotherapy (STTP).
The Immediate Management of the Patient with Ruptured Aneurysm: Open Versus Endovascular repair. Imperial College, London.
Interactions between the diet and gut microbes, metabolism and body composition in preterm infants
ComparIsoN oF Optimal Hypertension RegiMens (Part of the Ancestry Informative Markers in Hypertension (AIM HY)
IL-6 Inhibition in Patients with Depression and Low-grade Inflammation: The Insight Study
INTERIM: a randomised phase II feasibility study of INTERmittent versus continuous dosing of oral targeted combination therapy In patients with BRAFV600 mutant stage 3 unresectable or metastatic Melanoma
Effects of intravenous iron in COPD
The efficacy of Indwelling Pleural Catheter placement versus IPC placement PLUS sclerosant (talc) in patients with malignant pleural effusions managed exclusively as out-patients.
Increase in colonic PRopionate as a method of prEVENTing weight gain in young adults
A phase III multicentre randomised controlled trial to compare the efficacy of Robotically Assisted Radical Cystectomy and intracorporeal urinary diversion with Open Radical Cystectomy in patients with bladder cancer.
Clinical and cost evaluation of intensive support teams (IST) for adults with intellectual disabilities and challenging behaviour
Investigating the effect of post-operative home jejunostomy tube feeding on quality of life and nutritional parameters in patients with oesophago-gastric cancer: A pilot study
Clinical trial examining the effect of ketamine in combination with CBT on relapse rate in alcoholics.
Corneal cross-linking versus standard care in children with keratoconus; a randomised, multicentre, observer-masked trial of efficacy and safety
Ketogenic diet in infants with epilepsy (KIWE)
A multi-centre randomised, double blind, placebo-controlled, parallel group trial of the effectiveness of the nocturnal use of a Temperature Controlled Laminar Airflow (TLA) Device (Airsonett®) in adults with poorly-controlled, severe allergic asthma.
Randomized Controlled Trial to evaluate the effectiveness of an intervention using mobile technology for the treatment of depressive symptoms in people with diabetes and/or hypertension
A Randomised Controlled Trial Assessing the Impact of a Low Calorie Diet on Weight Loss in Obese Patients with Type 2 Diabetes Mellitus Treated with Insulin.
The aim of this study is to determine the efficacy of a novel therapy in the treatment for anorexia nervosa (AN), namely the Loughborough Eating disorders Activity theraPy (LEAP). LEAP is an innovative therapy that addresses the role of extreme exercise in the maintenance of AN using cognitive techniques and behavioural experiments and is fully integrated with an established manualised cognitive behavioural therapy for AN (mCBT-AN).
Health-Related Quality of Life in two treatment pathways for primary open angle glaucoma and ocular hypertension: a randomised controlled trial of initial selective laser trabeculoplasty versus conventional medical therapy.
Health-Related Quality of Life in two treatment pathways for newly diagnosed open angle glaucoma and ocular hypertension: an unmasked, multi-centre randomised controlled trial of initial selective laser trabeculoplasty versus conventional medical therapy
A Multi-site randomised controlled trial assessing the effectiveness of the Little Journey app at reducing peri-operative anxiety compared to standard care.
Weight Loss in Elderly Patients with Atrial Fibrillation (LOSE-AF): A Randomised Controlled Study
A Randomised Controlled Trial to test novel invitation methods and materials targeted to increase INFORMED uptake of lung cancer screening in individuals at high risk of lung cancer.
Impact of Liraglutide on cardiac function and structure in young adults with type 2 diabetes: an open-label, randomised active-comparator trial.
A Multicenter Randomized Controlled Trial of Therapeutic Hypothermia plus Magnesium Sulphate (MgSO4) vs. Therapeutic Hypothermia plus Placebo in the management of Term babies with Hypoxic Ischemic Encephalopathy. Hamad Medical Corporation.
Managing Agitation and Raising Quality of Life: feasibility trial of an intervention to improve the management of agitation in severe dementia
A study to determine if it is feasible to recruit into a randomised trial comparing (extended) pleurectomy decortication versus no pleurectomy decortication in the multimodality management of patients with malignant pleural mesothelioma. Papworth Hospital, Cambridge.
Treating neovascular age-related Macular degeneration with Aflibercept: a pilot 24 month, multi-centre randomised controlled trial comparing Standard Care with an individualised Treat and Extend regimen.
Methylphenidate versus placebo for fatigue in advanced cancer
Metformin for treating peripheral artery disease-related walking impairment
A pilot clinical trial and feasibility study comparing video-assisted thoracoscopic partial pleurectomy/decortication with indwelling pleural catheter in patients with trapped lung due to malignant pleural mesothelioma designed to address recruitment and randomisation uncertainties and sample size requirements for a Phase III trial
Diabetes Mobile Monitoring and Management Advantage Study
Can patients with multiple breast cancers in the same breast avoid mastectomy by having multiple lumpectomies to achieve equivalent rates of local breast cancer recurrence? A randomised controlled feasibility study.
Mental Health Intervention for Children with Epilepsy
MINeralocorticoid receptor antagonist pretreatment to MINIMISE reperfusion injury after ST-Elevation Myocardial Infarction (STEMI).
A randomized controlled trial of M.I.P.O. vs Intramedullary Nailing in fractured Tibias. The trial is being carried out at the Department of Surgery, King Abdul Aziz Medical City & King Abdullah International Medical Research Center, National Guard Health Affairs, Riyadh, Kingdom of Saudi Arabia.
Maraviroc in HIV Post Exposure Prophylaxis (MiPEP) Trial. Randomised controlled trial of the tolerability and completion of maraviroc compared to Kaletra in combination with Truvada for HIV post-exposure prophylaxis.
Managing Repetitive Behaviours: A clinical and cost effectiveness trial of a parent group intervention to manage restricted and repetitive behaviours in young children with Autism Spectrum Disorder
A proof of concept clinical trial investigating the effects of IL-1ra upon markers of inflammation in patients with Non-ST elevation myocardial infarction.
SIMVASTATIN IN SECONDARY PROGRESSIVE MULTIPLE SCLEROSIS - A double-blind, randomised, placebo-controlled multi-site study of high dose simvastatin treatment for secondary progressive multiple sclerosis: impact on vascular perfusion and oxidative damage
A phase 3 randomised, double blind, clinical trial investigating the effectiveness of repurposed simvastatin compared to placebo, in secondary progressive multiple sclerosis, in slowing the progression of disability
Randomized Controlled Trial Comparing Intracoronary Administration of Adenosine or Sodium Nitroprusside to Control for Attenuation of Microvascular Obstruction During Primary Percutaneous Coronary Intervention.
The TB Reach MXU Peer Study. A cluster randomised controlled trial evaluating the impact of peer educators on uptake of MXU screening for TB among homeless populations.
Comparison of Early Fusion in Anterior Cervical Decompression and Fusion (ACDF) with OsteoStrand™ Demineralized Bone Fibres and Cambria™ NanoMetalene® Implant Compared to Cabmria Uncoated Implant
Amino acid regimen and intravenous lipid composition in preterm parenteral nutrition: a randomised controlled trial of Nutritional Evaluation and Optimisation in Neonates.
A multicenter, prospective, randomized and subject blinded comparative study of AxoGuard Nerve Cap and Neurectomy for the Treatment of Symptomatic Neuroma and Prevention fo Recurrent End-Neuroma Pain
A phase II double-blind, randomised, placebo controlled trial of neuroprotection with phenytoin in acute optic neuritis. Sponsored by UCL and funded by the National Multiple Sclerosis Society and the Multiple Sclerosis Society of Great Britain and Northern Ireland.
A single blinded, multi-centre site, feasibility study to evaluate the ability to randomise men with prostate cancer into a trial comparing NeuroSAFE Robotic assisted radical prostatectomy (RALP) to standard Robotic assisted radical prostatectomy (RALP)
Clinical and cost-effectiveness of a New psychological intervention to support Independence in Dementia (NIDUS) for family carers and people living with dementia in their own homes: A randomised controlled trial
New technologies and tools to nutrition research - the example of phenotypic flexibility. Department of Investigative Medicine, Imperial College.
OFORT003 - Lyophilized Amniotic Fluid
OPtimal TIMing of Anticoagulation after acute ischaemic Stroke: a randomised controlled trial
Therapist-guided, parent-assisted remote digital behavioural intervention for tics in children and adolescents with Tourette syndrome: an internal pilot study and single-blind randomised controlled trial
BiOmarkers in Urine, anTihypeRtensive trEAtment and blood pressure Control in Hypertensive patients
Investigating the effects of a prebiotic supplement on learning and behaviour in children from academic year groups 3, 4 and 5, whose reading scores suggest there is room for improvement: a randomised placebo-controlled study. University of Oxford.
A Randomised Pilot Multiple Centre Trial of Conservative versus Liberal Oxygenation Targets in Critically Ill Children
Peri-Vascular adipose tissue inflammation Evaluated using coronary CT angiography (P-VECT Study)
What are the indications for Prescribing ANtiDepressAnts that will lead to a clinical benefit? A Phase IV, double-blind randomised placebo-controlled, parallel group multi-site trial; of sertraline compared to placebo in patients presenting with depressive symptoms in primary care where treatment with SSRIs is uncertain.
Effectiveness of a Mentalization-based therapeutic intervention for parents in conflict over their children: a randomised controlled trial. Coordinated by The Tavistock Centre for Couple Relationships (TCCR).
Partner: Platinum & Parp-Inhibitor for neo-adjuvant treatment of Triple Negative and/or BRCA Positive Breast Cancer
Problem Adaptation Therapy for individuals with mild to moderate dementia and depression
Promoting home-based walking exercise using telephone-based health coaching and activity monitoring for patients with peripheral artery disease (TeGeCoach)
A randomised, double-blind, placebo controlled trial of pramipexole in addition to mood stabilisers for patients with treatment resistant bipolar depression.
Evaluation of Positive Behaviour Support (PBS). Randomised controlled trial to evaluate the clinical and cost effectiveness of PBS following standardised training of staff in routine clinical practice in community intellectual disability services.
Primary care evaluation of a novel disposable neuromuscular electrical stimulation treatment for urinary incontinence: A randomised controlled trial
A randomised feasibility study of specialist physiotherapy for functional motor disorder
Randomised Phase II clinical trial PIONEER- A Pre-operative wIndOw study of Letrozole plus PR agonist (Megestrol Acetate) versus Letrozole aloNE in post-menopausal patients with ER-positive breast cancer
The Prognosis in Palliative care Study II (PiPS2): A multicentre prospective, observational, validation cohort study.
Low dose aspirin for the prevention of intrauterine growth restriction and preeclampsia in sickle cell pregnancy: a randomised controlled trial
PentoxIfylline and Tocopherol for the Treatment of Post-radiotherapy Fibrosis in Head and Neck Cancer Patients: a Feasibility Study
Platelets for Neonatal Transfusion (PlaNeT) study 2. A trial to compare two platelet transfusion thresholds, and establish whether a lower platelet transfusion threshold is as safe as a higher threshold.
PlasmaLyte Usage and kidney Transplant Outcomes in children
POMS2b: Prevention of Morbidity in Sickle Cell Disease (Phase II)
Problem-solving intervention for people who have been recently diagnosed as blind or partially-sighted. The primary aim of this trial is to determine whether blind and partially sighted people who undertake Problem-Solving Treatment (PST) demonstrate better psychological well-being, mobility and quality of life than those undergoing usual care (rehabilitation).
POWAR Study (Prophylaxis Of Wound infections - Antibiotics in Renal donation). Are prophylactic antibiotics necessary before laparoscopic living kidney donation? A double blind, randomised, controlled trial.
A randomised controlled trial of pre-operative high energy diet for the prevention of organ injury in cardiac surgery: The PRE-OP ENERGY Trial
Evaluating web based information for prevention of depression in general practice: an exploratory randomised controlled trial.
Prehabilitation in Elective Patients undergoing cardiac Surgery
PREvention STrategies for Adolescents at Risk of diabetes - A pilot study across 5 European countries.
Prevention Hydroxymethylglutaryl-CoA reductase inhibition with simvastatin in Acute lung injury to Reduce Pulmonary dysfunction
A randomised double-blind controlled phase III study to compare the efficacy and safety of intravenous ferric carboxymaltose with placebo in patients with anaemia undergoing major open abdominal surgery.
Prediction and management of cardiovascular risk for people with severe mental illnesses.
Pulmonary protection with low frequency ventilation during cardiopulmonary bypass: a prospective randomised study.
Preventing cardiac damage in patients treated for breast cancer and lymphoma: a phase 3 Randomised, Open label, blinded endpoint, superiority trial of enalapril to prevent Anthracycline-induced CardioToxicity
Impact of anatomical bladder neck preservation on functional and oncologic outcomes after robotic-assisted laparoscopic radical Prostatectomy
PeRcutaneous cOronary intervention of native Coronary arTery versus venous bypass graft in patients with prior cORonary artery bypass graft surgery - the PROCTOR trial
Algorithmic Protamine Dosing for Reversal of Heparin after Cardiopulmonary Bypass (PRODOSE)
PRedicting Outcomes For Crohn’s dIsease using a moLecular biomarkEr trial
ChemoPROphyLaxIs For covId-19 infeCtion (the PROLIFIC trial)
Pain Reduction with Oral Methotrexate in knee Osteoarthritis, a pragmatic phase III trial of Treatment Effectiveness
Pro-active fecal calprotectin monitoring to improve patient outcomes in ulcerative colitis: a prospective randomised control trial
Platelet Responsiveness and Outcome from Platelet Transfusion. Does inherent variation in donor platelet function affect the clinical efficacy of apheresis platelets? A randomised double blind single centre trial.
The PRomotion Of Physical activity through structured Education with differing Levels of ongoing Support for those with prediabetes (PROPELS) - randomised controlled trial in a diverse multi-ethnic community.
IRST100.47 - PROTECT
A multi-centre, randomised controlled trial of the clinical and cost-effectiveness of early, goal-directed, protocolised resuscitation for emerging septic shock.
A Randomised trial of Pulmonary Metastasectomy in Colorectal Cancer. This is a two-stage randomised feasibility study. Patients will be firstly registered for evaluation and if subsequently eligible, randomised to active monitoring versus active monitoring with pulmonary metastasectomy.
Qatar Diabetes Mobile Application Trial
160382 Dr Reddy's - Oral DFD-29 for the Treatment of Rosacea
Reducing pathology in Alzheimer's Disease through Angiotensin taRgeting. University of Bristol School of Social & Community Medicine
Research into Antipsychotic Discontinuation and Reduction
A randomised controlled trial of very early versus delayed angiography +/-Intervention on outcomes in patients with non ST-elevation myocardial infarction
Rivaroxaban in Antiphospholipid Syndrome (RAPS) Trial (EudraCT 2012-002345-38).
Pilot study for a randomised controlled trial of home based reach to grasp training for people after stroke.
A randomised study of interferon-free treatment for recently acquired hepatitis C in people who inject drugs and people with HIV coinfection (REACT)
REperfusion with Cooling in CerebraL Acute IscheMia II
A randomized controlled trial of red cell rejuvenation for the attenuation of transfusion associated organ injury in cardiac surgery: the REDJUVENATE trial
A randomised controlled trial evaluating the efficacy of indwelling pleural catheters in persistent non-malignant symptomatic pleural effusions.
A randomised controlled trial of red cell washing for the attenuation of transfusion associated organ injury in cardiac surgery.
The REJOIN study (REhabilitation for Job and Occupational INdependence) – a feasibility study of a randomised controlled trial to evaluate a vocational rehabilitation intervention for people with cancer.
Randomised, double-blind, placebo controlled multi-centre study to assess the efficacy, tolerability and safety of Enterosgel® in the treatment of Irritable Bowel Syndrome with Diarrhoea (IBS-D) in adults (RELIEVE IBS-D)
A randomized trial of Rituximab in induction therapy for living donor renal transplantation. This is a Phase IV randomised, open label, controlled trial.
KAI Research, Inc.
Randomised double blind placebo-controlled trial to determine if remote ischaemic preconditioning (RIPC) improves renal function after transplantation.
A multicentre, non-blinded, randomised controlled trial to assess the impact of Regular Early SPEcialist symptom Control Treatment on quality of life in malignant Mesothelioma – “RESPECT-Meso”
RESPONSE: REmediation of SPatial NEglect Trial. Posit Science.
pRotective vEntilation with veno-venouS lung assisT in respiratory failure
The Effect of Sildenafil (REVATIO®) on Post Cardiac Surgery Acute Kidney Injury (AKI): A Randomised, Placebo-controlled Clinical Trial.
Revascularisation for Ischaemic Ventricular Dysfunction - a multicentre prospective randomised open controlled trial. The aim is to evaluate the efficacy and safety of percutaneous coronary intervention compared to optimal medical therapy alone for ischaemic left ventricular dysfunction.
Remote ischaemic preconditioning for brain protection in paediatric cardiac surgery. This trial is run by UCL Institute of Cardiovascular Science & Great Ormond Street Hospital.
Retinopathy and OSA Trial. A randomised controlled trial of Continuous Positive Airway Pressure in patients with impaired vision due to diabetic retinopathy and concurrent Obstructive Sleep Apnoea. A multi-centre trial being conducted by the Oxford Respiratory Trials Unit (University of Oxford).
How can we optimise inhaled beta2 agonist dose as 'reliever' medicine for wheezy pre-school children? Brighton & Sussex University Hospitals NHS Trust
A randomised placebo-controlled trial to assess the effect of melatonin on circadian sleep-wake disturbances in ocular disease
Code break application for the Symptomatic versus Antibiotic Treatment of urinary tract INfection trial.
A double blind randomised controlled trial to determine whether IV administered Kineret® inhibits the central nervous system (CNS) inflammatory response in patients with SAH
A novel diagnostic screening procedure for antipsychotic-induced movement disorders.
Smoking Cessation for Severe Mental Ill Health Trial
A randomized controlled trial of remedial after-school support classes in rural Gambia
SGLT-2 INHIBITOR EMPAGLIFLOZIN EFFECTS ON APPETITE AND WEIGHT REGULATION: A RANDOMISED DOUBLE-BLIND PLACEBO-CONTROLLED TRIAL
Study to Evaluate the Prevalence and Treatment of women with Uterine Malformation.
A feasibility study to inform the development of a multicentre randomised controlled trial of an asthma-tailored pulmonary rehabilitation programme versus usual care for individuals with severe asthma.
Effect of insulin sensitization on insulin like growth factor-1 responses to growth hormone treatment in children born small for gestational age.
The Efficacy of Sonographic and Biological Pleurodesis Indicators of Malignant Pleural Effusion – a randomised trial
Can simvastatin significantly reduce the amount of immunosuppressive medication required by patients with sight threatening uveitis? A phase IIb, single site, randomized, placebo controlled, double blinded trial. A UCL trial funded by the Moulton Trust.
A randomised phase II double-blinded placebo-controlled trial of intravenous immunoglobulins and rituximab in patients with antibody-associated psychosis
Surgical and large bore pleural procedures in Malignant Pleural Mesothelioma And Radiotherapy Trial. A multi-centre trial being conducted by the Oxford Respiratory Trials Unit (University of Oxford).
Simplified Monitoring - A Randomised Trial in hepatitis C
Diabetes Prevention using SMS trial. A mobile phone intervention for lifestyle change in people with impaired glucose regulation (high risk at developing type 2 diabetes). Imperial College London.
SNAP (Silicon Nitride and PEEK) Trial. A Clinical Study of the Amedica Corporation Interbody Fusion Devices for PLIF. The primary objective is to compare the average improvement in Roland Morris Disability Questionnaire for Valeo OL patients versus those that receive similarly-shaped PEEK cages.
Surgery for Olecranon Fractures in the Elderly: a randomised controlled trial of operative versus non-operative treatment
Omega–3 fatty acids for the prophylaxis of acute attacks of gout on initiating urate lowering treatment – feasibility study for a randomised controlled trial
Studying Pleuroscopy In Routine Pleural Infection Treatment
A double blind, placebo controlled, randomised dose escalation trial to investigate the safety and efficacy of topical salbutamol in the improvement of scar appearance when applied to approximated wound margins in healthy volunteers.
Sedentary behaviour in older adults: investigating a new therapeutic paradigm. Work Package 3: Investigating the effect of sedentary time, reduced sedentary time and increased light-intensity physical activity on metabolic and psychological health in older adults. University of Leicester.
STopping Aminosalicylate Therapy in Inactive Crohn’s Disease (STATIC) Study: A Randomized, Open-label, Non-inferiority Trial
RandomiSed conTrolled trial with prAvasTatin versus placebo for preventIoN of preeclampsia
Study of two regimens of TicagrElor compared to clopidogrel in patients undergoing ELective Percutaneous Coronary Intervention (STEEL PCI). Sheffield Teaching Hospitals NHS Foundation Trust.
Sodium InTake In Chronic Kidney Disease (STICK): A Randomised Controlled Trial
Effectiveness and cost of integrating a protocol with use of liraglutide 3.0 mg into an obesity service
Telomerase ACTivator to reverse Immunosenescence in Acute Coronary Syndrome: a double-blind, phase II, pilot randomised controlled trial
mulTi-Arm Therapeutic study in pre-ICu patients admitted with Covid-19 – Experimental drugs and mechanisms
mulTiArm Therapeutic study in pre-Icu patients Admitted with Covid-19 – Repurposed drugs
A randomised controlled Trial of high and low dose Avastin® for Neovascular macular Degeneration in the East Midlands.
Evaluating the efficacy of thoracoscopy and talc poudrage versus pleurodesis using talc slurry. A multi-centre trial being conducted by the Oxford Respiratory Trials Unit (University of Oxford).
Total Ankle Replacement Versus Arthrodesis Trial: A randomised, multi-centre, non-blinded, prospective, parallel group trial of total ankle replacement (TAR) versus ankle arthrodesis, comparing clinical outcomes and cost-effectiveness.
A Randomised Controlled Trial Investigating the Pharmacodynamic Effect of Ticagrelor Monotherapy on Platelet Reactivity in Patients with Coronary Artery Disease: The TEMPLATE Study
Trial of Exercise To Prevent Hypertension in Young Adults
Multi-centre, Observational, Post-Market, Real World Registry to assess Outcomes of Patients Treated with the Altura Endograft System for Endovascular Abdominal Aortic Aneurysm Repair
A randomised controlled comparison of effectiveness of facemask preoxygenation and Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE) in bariatric patients undergoing general anaesthesia.
Investigating Aspirin and Ticagrelor for the prevention of Tumour cell-induced platelet aggregation
PILOT STUDY for the Tight K TRIAL. Arrhythmias on the cardiac intensive care unit - does maintenance of high-normal serum potassium levels matter?
Technology Integrated Health Management for dementia
First-in-human open label feasibility study to assess the safety of TIPS microspheres in perianal fistulas
A Randomized Cross-over Study to Evaluate Local Tolerability Following Subcutaneous Administration of TV-46046
Trial of Sertraline versus Cognitive behavioural therapy in generalised Anxiety
A randomised controlled trial of targeted oxygen therapy in mechanically ventilated critically ill patients. (A feasibility study)
Code break application for a randomized double blind placebo controlled clinical trial of anti-b-cell therapy in patients with primary Sjögren’s Syndrome.
An Open Label Study to Assess the Safety and Efficacy of Neural Allo-Transplantation with Fetal Ventral Mesencephalic Tissue in Patients with Parkinson's disease. A trial coordinated by the Cambridge Centre for Brain Repair.
Twin Reversed Arterial Perfusion Intervention STudy
Pharmacokinetics of intramuscular tranexamic acid in trauma patients: a clinical trial (Acronym: Trauma-INTACT)
The Evaluation of blood pressure treatment stratified according to Central Aortic Systolic Pressure (CASP) in Young Hypertensive Patients
TRial to EvaluaAte Tranexamic acid in Thrombocytopenia.
A randomised controlled pilot trial of the feasibility and safety of therapy withdrawal in asymptomatic patients with a prior diagnosis of dilated cardiomyopathy and recovered cardiac function
A randomised controlled trial of Polyglactin 910 Triclosan coated sutures versus standard Polyglactin 910 sutures in patients aged 18 or over undergoing primary unilateral hip and knee arthroplasty in the Department of Trauma and Orthopaedics at University College London Hospital
A Phase 2b randomised, double blind, placebo-controlled trial of trimetazidine therapy in patients with non-obstructive hypertrophic cardiomyopathy (HCM). The sponsor is University College London (UCL).
A Randomised Parallel Group Double-Blind Phase II Study to Assess the Activity of TroVax® (MVA-5T4) Versus Placebo in Patients with Relapsed Asymptomatic Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer.
Treatment of Social Cognition in Schizophrenia Trial.
Can text messages increase safer sexual health behaviours in young people? Pilot Trial
Conventional versus minimally invasive mitral valve repair for version 2
Phase II Multi-centre, double-blind, randomized trial of Ustekinumab in adolescents with new-onset type 1 diabetes
Impact of guided care with the Vectra DA multi-biomarker disease activity (MBDA) blood test on clinical outcomes and pharmaceutical utilization in patients with rheumatoid arthritis: A prospective, randomized study
A randomised controlled trial of Pre-surgery Sodium ValpRoate, for the prevention of organ injury in cardiac surgery: THE Val-CARD TRIAL
Valuing Active Life in Dementia
Vitamin D Supplementation in Children With Obesity-Related Asthma (VDORA1)
Preoperative Volume Replacement vs. usual care in Diabetic patients having CABG surgery, a randomised controlled Trial.
Whole Body Vibration
Vitamin K in kidney Transplant Organ Recipients: Investigating vEssel Stiffness
VIdeo assisted thoracoscopic lobectomy versus conventional Open LobEcTomy for lung cancer, a multi-centre randomised controlled trial with an internal pilot
The VIP trial: a randomised controlled trial of the clinical and cost effectiveness of a Victim Improvement Package (VIP) for the reduction of chronic symptoms of depression or anxiety in older victims of common crime.
Does Laryngeal Reinnervation or Type I Thyroplasty give better voice results for patients with Unilateral Vocal Fold Paralysis (VOCALIST): a feasibility study
Individually randomised controlled trial comparing clinic led face-to-face treatment observation (DOT) versus virtually observed treatment (VOT) organised by TB Reach study team to inform optimal treatment delivery.
An open-label, multi-centre, randomised, switch study to evaluate the virological efficacy over 96 weeks of 2-drug therapy with DTG/RPV FDC in antiretroviral treatment-experienced HIV-1 infected subjects virologically suppressed with NNRTIS resistance mutation K103N
Tranexamic Acid for the Treatment of Postpartum Haemorrhage: an international Randomised, Double Blind, Placebo Controlled Trial.
WOUNDCHEK Protease Status Point of Care (POC) Diagnostic Test. A Prospective, Multi Centre, Randomised, Clinical Study on Venous Leg Ulcers and Diabetic Foot Ulcers.
Effects of Long Term Antibiotic Therapy on Exacerbation Rate in Stable COPD Patients. Imperial College.
Targeted retreatment of incompletely recovered COPD exacerbations with ciprofloxacin: a double-blind, randomised, placebo-controlled, multicentre Phase III trial. Imperial College.
A multicenter randomized controlled trial testing the app 'Young with Diabetes'
Zol-A Trial eligibility
A double blind randomised controlled trial examining the effect of intravenous zoledronic acid on pleural tumour progression, pleural fluid production, breathlessness and quality of life in patients with malignant pleural disease.
Prognostic model for predicting outcome after traumatic brain injury
A prognostic model that may be used as an aid to estimate the risk of incident locomotor disability within 7 years. Developed from data collected in the British Women's Heart and Health Study.
A prognostic model that may be used as an aid to estimate the risk of coronary and cardiovascular death in patients with suspected angina.